Division of Molecular Hematology, Lund University
Photo of Cristian Bellodi
project title

The role of RNA modification in cancer development

funded by

Erling-Perssons stiftelse

This proposal aims to unravel a completely new facet of gene expression governed by RNA pseudouridylation (Ψ), the most abundant single nucleoside RNA modification in living organisms, which directly impacts the stem cell transcriptome during normal and malignant hematopoiesis. Importantly, RNA modification is newly emerging as a key mechanism to coordinate gene expression in stem cells.

Recent data show that Ψ modifications are dynamic and widespread among RNAs in cells and tissues, suggesting that Ψ may rapidly rewire a cell’s transcriptome. This proposal will be transformative in hematopoietic research by defining for the first time a new RNA-pseudouridylation ‘code’ that drives distinct genetic programs in stem and cancer cells.

January 2016

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